Faculty of Science

Department of Pharmacy

NUS Pharmacy MedChem Symposium 2010

Venue: Kent Ridge Guild Hall, National University of Singapore

DAY ONE: 1st September 2010, Wednesday:

8:30 – 9:00 AM Registration
9:00 – 9:30 AM Welcome Address by Guest of Honor: Mr Lim Chuan Poh, Chairman of A*STAR
9:30 – 10:20 AM Keynote Speaker: Prof Dhiren Thakker, University of North Carolina
Title: Changing Landscape of Drug Discovery in the 21st Century
10:20 – 10:40 AM Tea break

Session 1: Computational Methods for Lead Discovery
10:40 – 11:20 AM Prof Chen Yu Zong, National University of Singapore
Title: Virtual Screening of Selective Multi-Target Kinase Inhibitors by Combinatorial Support Vector Machines
11:20 – 12:00 PM Dr Chandra Verma, Bioinformatics Institute
Title: Role of protein dynamics in drug design
12:00 – 12:30 PM Dr Yap Chun Wei, National University of Singapore
Title: Free drug discovery software
12:30 – 1:50 PM Lunch (Sponsored by Bruker)

Session 2: Analog-based Methods for Lead Discovery
1:50 – 2:40 PM Keynote Speaker: Dr Christina Chai, Institute of Chemical and Engineering Sciences
Title: Natural products as leads in drug discovery
2:40 – 3:20 PM Prof Hou Ai-Jun, Fudan University
Title: Drug discovery and development from Chinese medicinal plants: a shortcut way

Graduate student/postdoc talks
3:20 – 3:35 PM Galderma local award recipient: Sim Hong May
Title: In vitro mode of action studies and in vivo evaluation of aurones and related analogues as modulators of ABCG2
3:35 – 4:00 PM Tea break
4:00 – 4:15 PM GSK Travel award recipient: Yoganjaneyulu Kasetti
Title: Computational and synthetic studies on PPAR agonists
4:15 – 4:30 PM NUSS Travel award recipient: Jiang Yun
Title: Anti-complementary Constituents and Pharmacological Effects of Houttuynia cordata Thunb
4:30 – 4:45 PM Galderma Travel award recipient: Ranajit Nivrutti Shinde
Title: Role of Alpha7 Helix in the Binding of Allosteric Inhibitors of Protein Tyrosine Phosphatase 1b
4:45 - 5:00 PM Agilent Travel award recipient: Bai Renren
Title: Structure Modification and Biological Evaluation of the Derivatives of (±)7,8-Dihydroxy-3-Methyl-Isochromanone-4


DAY TWO: 2nd September 2010, Thursday:

Session 3: ADMET Assessment in Drug Discovery
8:55 – 9:00 AM Day 2 introduction
9:00 – 9:50 AM Keynote Speaker: Prof Sidney Nelson, University of Washington
Title: How Knowledge of Reactive Metabolites Can Aid in the Drug Discovery Process
9:50 – 10:30 AM Prof Alexander Tropsha, University of North Carolina
Title: Novel approaches to predictive ADME/Tox modeling integrating chemical descriptors and short-term biological assay data.
10:30 – 10:50 AM Tea break (Sponsored by Agilent Technologies)
10:50 – 11:30 AM Prof Kim Brouwer, University of North Carolina
Title: Hepatobiliary Drug Disposition: Tools to Predict Transporter-Based Drug-Drug Interactions and Hepatotoxicity
11:30 – 12:10 PM Dr Brian Dymock, S*BIO
Title: Falling off the permeability cliff: balancing molecular properties in the design of orally available PDK1 inhibitors for the treatment of cancer
12:10 – 1:30 PM Lunch (Sponsored by BD)

Session 4: Disease-Specific Drug Discovery Projects
1:30 – 2:20 PM Keynote Speaker: A/Prof Go Mei Lin, National University of Singapore
Title: Aurones as modulators of ABCG2 transport activity
2:20 – 3:00 PM A/Prof Chui Wai Keung, National University of Singapore
Title: Developing the 1,3,5-triazine scaffold into potential anticancer agents
3:00 – 3:40 PM Dr Giorgia Pastorin, National University of Singapore
Title: Pyrazolo-triazolo-pyrimidine scaffold as potent and highly selective hA3 adenosine receptor’s antagonist
3:40 – 4:00 PM Tea break
4:00 – 4:30 PM Dr Ho Han Kiat, National University of Singapore
Title: Phenotype-based screening approach to uncover new multi-targeting kinase inhibitors

Graduate student/postdoc talks
4:30 – 4:45 PM Galderma local award recipient: Leow Pay Chin
Title: Functionalization of curcumin analogues as potent Wnt antagonists in osteosarcoma
4:45 – 5:00 PM NUSS Travel award recipient: Hoang Lam Pham
Title: Synthesis and characterisation of Quil A cationic derivatives with application in protein- and gene-based subunit vaccines