Faculty of Science

Department of Pharmacy

 

   

publications

 

international peer reviewed publication

2014

  1. LC Phua, XP Chue, PK Koh, PY Cheah, ECY Chan* and HK Ho*. Global fecal microRNA profiling in the identification of biomarkers for colorectal cancer screening among Asians. Oncology Reports 32 (May 2014) 97-104.
  2. EA Bard-Chapeau, A Nguyen, AG Rust, A Sayadi, P Lee, BQ Chua, LS New, J de Jong, JM Ward, CKY Chin, V Chew, HC Toh, J Abastado, T Benoukraf , R Soong, FA Bard, AJ Dupuy, RL Johnson, GK Radda, ECY Chan, LFA Wessels, DJ Adams, NA Jenkins and NG Copeland*. Transposon mutagenesis identifies genes driving hepatocellular carcinoma in a chronic hepatitis B mouse model. Nature Genetics 46 (Jan 2014) 24-32.
  3. MD Damavandi, ECY Chan, JP Kraus, PC Ho and TS Kang*. Development of an UPLC-MS/MS method for assaying the enzymatic activity of propionyl coenzyme-A carboxylase. Bioanalysis 6 (February 2014) 335-348.
  4. LC Phua, XP Chue, PK Koh, PY Cheah, HK Ho* and ECY Chan*. Non-invasive fecal metabonomic detection of colorectal cancer. Cancer Biology & Therapy 15 (April 2014) 389-397.
  5. P Bahety, YM Tan, Y Hong, L Zhang, ECY Chan* and PL Ee*. Metabotyping of docosahexaenoic acid - treated Alzheimer’s disease cell model. PLOS ONE (February 2014) DOI: 10.1371/journal.pone.0090123.

 

2013

  1. LC Phua, PK Koh, PY Cheah, HK Ho* and ECY Chan*. Global gas chromatography/time-of-flight mass spectrometry (GC/TOFMS)-based metabonomic profiling of lyophilized human feces. Journal of Chromatography B 937 (October 2013) 103-113.
  2. KK Pasikanti, K Esuvaranathan,YJ Hong, PC Ho, R Mahendran, LRN Mani, E Chiong and ECY Chan*. Urinary metabotyping of bladder cancer using two-dimensional gas chromatography time-of-flight mass spectrometry. Journal of Proteome Research 12 (September 2013) 3865-3873.
  3. BD Prakash, K Esuvaranathan,PC Ho, KK Pasikanti, ECY Chan and CW Yap*. An automated Pearson's correlation change classification (APC3) approach for GC/MS metabonomic data using total ion chromatogram (TIC). Analyst 138 (May 2013) 2883-2889. 
  4. HH Cheong, J Masilamani, ECY Chan, SY Chan* and TT Phan*. Metabolically functional hepatocyte-like cells from human umbilical cord lining epithelial cells. Assay and Drug Development Technologies 11 (March 2013) 130-138.
  5. LC Phua, M Mal, PK Koh, PY Cheah, ECY Chan* and HK Ho*. Investigating the roles of nucleoside transporters in the resistance of colorectal cancer to 5-fluorouracil therapy. Cancer Chemotherapy and Pharmacology 71 (March 2013) 817-823.
  6. LS New, TP Lim, JW Oh, GJS Cheah, AL Kwa and ECY Chan*. Optimizing hollow-fiber-based pharmacokinetic assay via chemical stability study to account for inaccurate simulated clearance of rifampicin. Analytical and Bioanalytical Chemistry 405 (4) (January 2013) 1407-1415.

 

2012

  1. ZP Hu, ER Browne, T Liu, TE Angel, PC Ho and ECY Chan*. Metabonomic profiling of TASTPM transgenic Alzheimer's disease mouse model. Journal of Proteome Research 11 (December 2012) 5903-5913.
  2. S Saha, DSZ Chan, CY Lee, W Wong, LS New, WK Chui, ECY Chan* and HK Ho*. Pyrrolidinediones reduce the toxicity of thiazolidinediones and modify their anti-diabetic and anti-cancer properties. European Journal of Pharmacology 697 (2012) 13-23.
  3. YL Teo, M Saetaew, S Chanthawong, YS Yap, ECY Chan, HK Ho and A Chan*. Effect of CYP3A4 inducer dexamethasone on hepatotoxicity of lapatinib: clinical and in vitro evidence. Breast Cancer Research and Treatment 133 (June 2012) 703-711.
  4. WPK Ching, SH Thng, AP Hui, DY Lee, ECY Chan* and YS Ho*. LC-MS-based metabolic characterization of high monoclonal antibody-producing chinese hamster ovary cells. Biotechnology and Bioengineering 109 (December 2012) 3103-3111.
  5. ECY Chan*, LS New, TB Chua, CW Yap, HK Ho and SD Nelson. Interaction of lapatinib with cytochrome P450 3A5. Drug Metabolism & Disposition 40 (July 2012) 1414-1422.
  6. HT Chng, HK Ho, CW Yap, SH Lam and ECY Chan*. An investigation of the bioactivation potential and metabolism profile of zebrafish versus human. Journal of Biomolecular Screening 17 (August 2012) 974-986.
  7. ECY Chan*. Thomas O. Metz (Ed.): Metabolic profiling. Methods and protocols. Analytical Bioanalytical Chemistry 403 (2012) 2465-2466.
  8. M Mal, PK Koh, PY Cheah and ECY Chan*. Metabotyping of human colorectal cancer using two-dimensional gas chromatography mass spectrometry. Analytical Bioanalytical Chemistry 403 (2012) 483-493.

 

2011

  1. T Nema, ECY Chan and PC Ho*. Efficiency of a miniaturized silica monolithic cartridge in reducing matrix ions as demonstrated in the simultaneous extraction of morphine and codeine from urine samples for quantification with liquid chromatography-tandem mass spectrometry (LC-MS/MS). Journal of Mass Spectrometry 46 (2011) 891-900.
  2. LY Chen, L Zhou*, ECY Chan, J Neo and R Beuerman. Characterization of the human tear metabolome by LC-MS/MS. Journal of Proteome Research 10 (2011) 4876-4882.
  3. CY Chan, LS New, HK Ho and ECY Chan*. Reversible time-dependent inhibition of cytochrome P450 enzymes by duloxetine and inertness of its thiophene ring towards bioactivation. Toxicology Letters 206 (2011) 314-324.
  4. KM Banday, KK Pasikanti, ECY Chan, R Singla, KVS Rao, VA Chauhan* and RK Nanda*. Urine volatile organic compounds could discriminate tuberculosis patients from healthy subjects. Analytical Chemistry 83 (2011) 5526-5534.
  5. ECY Chan*, KK Pasikanti and JK Nicholson. Global urinary metabolic profiling procedures using gas chromatography mass spectrometry. Nature Protocols 6 (2011) 1483-1499.
  6. T Nema, ECY Chan and PC Ho*. Extraction of ketamine from urine using a miniature silica monolithic cartridge followed by quantification with liquid chromatography tandem mass spectrometry (LC-MS/MS). Journal of Separation Science 10 (2011) 2079-2087.
  7. KL Chang, LS New, M Mal, CW Goh, CC AW, ER Browne and ECY Chan*. Metabolic profiling of 3-nitroproprionic acid early-stage Huntington's disease rat model using gas chromatography time-of-flight mass spectrometry. Journal of Proteome Research 10 (2011) 2079-2087.
  8. H Takakusa, MD Wahlin, C Zhao, KL Hanson, LS New, ECY Chan and SD Nelson*. Metabolite-intermediate complex formation of human cytochrome P450 3A4 by lapatinib. Drug Metabolism & Disposition 39 (2011) 1022-1030.
  9. H Sukardi, HT Chng, ECY Chan, Z Gong and SH Lam*. Zebrafish for drug toxicity screening: bridging the in vitro cell-based models and in vivo mammalian models. Expert Opinion on Drug Metabolism and Toxicology 7 (2011) 579-589.
  10. DF Toh, DN Patel, ECY Chan, A Yeo, SY Neo and HL Koh*. Anti-proliferative effects of raw and steamed extracts of Panax notoginseng and its ginsenoside constituents on human liver cancer cells. Chinese Medicine 6 (2011) 1-9.
  11. M Mal, PK Koh, PY Cheah and ECY Chan*. UPLC/MS/MS targeted profiling of arachidonic acid and eicosanoids in human colorectal cancer. Rapid Communications in Mass Spectrometry 25 (2011) 755-764.
  12. DJY Ng, KK Pasikanti and ECY Chan*. Trend analysis of metabonomics and systemic review of metabonomics-derived cancer marker metabolites. Metabolomics 7 (2011) 155-178.

 

2010

  1. YT Koh, KK Pasikanti, CW Yap* and ECY Chan*. Comparative evaluation of software for retention time alignment of gas chromatography/time-of-flight mass spectrometry-based metabonomic data. Journal of Chromatography A 1217 (2010) 8308-8316.
  2. KK Pasikanti, J Norasmara, S Cai, R Mahendran, K Esuvaranathan, PC Ho and ECY Chan*. Metabolic footrpinting of tumorigenic and non-tumorigenic uroepithelial cells using two-dimensional gas chromatography time-of-flight mass spectrometry. Analytical and Bioanalytical Chemistry 398 (2010) 1285-1293.
  3. WC Teng, JW Oh, LS New, MD Wahlin, SD Nelson, HK Ho and ECY Chan*. Mechanism-based inactivation of cytochrome P450 3A4 by lapatinib. Molecular Pharmacology 78 (2010) 693-703.
  4. T Nema, ECY Chan and PC Ho*. Application of silica based monolith as solid phase extraction cartridge for extracting polar compounds from urine. Talanta 82 (2010) 488-494.
  5. X Ma and ECY Chan*. On-line chromatographic screening of matrix metalloproteinase inhibitors using immobilized MMP-9 enzyme reactor. Journal of Chromatography B 878 (2010) 1777-1783.
  6. KK Pasikanti, K Esuvaranathan, PC Ho, R Mahendran, R Kamaraj, QH Wu, E Chiong and ECY Chan*. Noninvasive urinary metabonomic diagnosis of human bladder cancer. Journal of Proteome Research 9 (2010) 2988-2995.   
  7. S Saha, LS New, HK Ho, WK Chui, ECY Chan*. Direct toxicity effects of sulfo-conjugated troglitazone on human hepatocytes. Toxicology Letters 195 (2010) 135-141.  
  8. DF Toh, LS New, HL Koh* and ECY Chan*. Ultra-high performance liquid chromatography / time-of-flight mass spectrometry (UHPLC/TOFMS) for time-dependent profiling of raw and steamed Panax notoginsengJournal of Pharmaceutical and Biomedical Analysis 52 (2010) 43-50.
  9. S Saha, LS New, HK Ho, WK Chui and ECY Chan*. Investigation of the role of the thiazolidinedione ring of troglitazone in inducing hepatotoxicity. Toxicology Letters 192 (2010) 141-149.
  10. X Ma and ECY Chan*. Fluorescence-based liver microsomal assay for screening of pharmaceutical reactive metabolites using glutathione conjugated 96-well plates. Bioconjugate Chemistry 21 (2010) 46-55.
  11. HT Chng, LS New, AH Neo, CW Goh, ER Browne and ECY Chan*. A sensitive LC/MS/MS bioanalysis assay of orally-administered lipoic acid in rat blood and brain tissue. Journal of Pharmaceutical and Biomedical Analysis 51 (2010) 754-757.

 

2009

  1. DPQ Goh, AH Neo, CW Goh, CC Aw, LS New, WS Chen, Z Atcha, ER Browne and ECY Chan*. Metabolic Profiling of Rat Brain and Cognitive Behavioral Tasks: Potential Complementary Strategies in Preclinical Cognition Enhancement Research. Journal of Proteome Research 8 (2009) 5679-5690.
  2. R  Kashimshetty, VG Desai, VM Kale, T Lee, CL Moland, WS Branham, LS New, ECY Chan, H Younis and UA Boelsterli*. Underlying mitochondrial dysfunction triggers flutamide-induced oxidative liver injury in a mouse model of idiosyncratic drug toxicity. Toxicology and Applied Pharmacology 238 (2009) 150-159.
  3. M Mal, PK Koh, PY Cheah and ECY Chan*. Development and validation of a gas chromatography mass spectrometry (GC/MS) method for the metabolic profiling of human colon tissue. Rapid Communications in Mass Spectrometry 23 (2009) 487-494.
  4. ECY Chan*, LS New, CW Yap and LT Goh. Pharmaceutical metabolite profiling using quadrupole/ ion mobility spectrometry/ time-of-flight mass spectrometry. Rapid Communications in Mass Spectrometry 23 (2009) 384-394.
  5. ECY Chan*, PK Koh, M Mal, PY Cheah, KW Eu, A Backshall, R Cavill, JK Nicholson and H Keun. Metabolic profiling of human colorectal cancer using high-resolution magic angle spinning nuclear magnetic resonance (HR-MAS NMR) spectroscopy and gas chromatography mass spectrometry (GC/MS). Journal of Proteome Research 8 (2009) 351-361.
  6. HT Chng, LS New, AH Neo, CW Goh, ER Browne and ECY Chan*. Distribution study of orally administered lipoic acid in rat brain tissues. Brain Research 1251 (2009) 80-86.

 

2008

  1. KK Pasikanti, PC Ho and ECY Chan*. Development and validation of a GC/MS metabonomic platform for the global profiling of urinary metabolites. Rapid Communications in Mass Spectrometry 22 (2008) 2984-2992.
  2. LC Phua, LS New, CW Goh, AH Neo, ER Browne and ECY Chan*. Investigation of the drug-drug Interaction between α-lipoic Acid and valproate via mitochondrial β-oxidation. Pharmaceutical Research 25 (2008) 2639-2649.
  3. WS Law, PY Huang, ES Ong*, CN Ong, SFY Li, KK Pasikanti, ECY Chan. Metabonomics investigation of human urine after ingestion of green tea with gas chromatography/mass spectrometry, liquid chromatography/mass spectrometry and 1H NMR spectroscopy. Rapid Communications in Mass Spectrometry 22 (2008) 2436-2446.
  4. SC Tan, LS New and ECY Chan*. Prevention of acetaminophen (APAP) induced hepatotoxicity by leflunomide via inhibition of APAP biotransformation to N-acetyl-p-benzoquinone imine. Toxicology Letters 180 (2008) 174-181.
  5. QM Seah, LS New, ECY Chan, UA Boelsterli*. Oxidative bioactivation and toxicity of leflunomide in immortalized human hepatocytes and kinetics of the non-enzymatic conversion to its major metabolite, A77-1726. Drug Metabolism Letters 2 (2008) 153-157.
  6. KK Pasikanti, PC Ho and ECY Chan*. Gas Chromatography/Mass Spectrometry in Metabolic Profiling of Biological Fluids. Journal of Chromatography B 871 (2008) 202-211. Top 25 Most Cited Review Article (2008-2009)  
  7. ECY Chan*. Enhancing pharmaceutical analysis laboratory classes via the measurement of minerals in Berocca® effervescent tablets. Pharmacy Education 8 (2008) 53-57.
  8. LS New and ECY Chan*.Evaluation of BEH C18, BEH HILIC and HSS T3 (C18) Column Chemistries for the UPLC/MS/MS Analysis of Glutathione, Glutathione Disulfide and Ophthalmic Acid in Mouse Liver and Human Plasma.  Journal of Chromatographic Science 48 (2008) 209-214 (Special UPLC Issue).

 

2007

  1. ECY Chan* and LS New. In Vitro Metabolism of Leflunomide by Mouse and Human Liver Microsomes. Drug Metabolism Letters 1 (2007) 299-305. 
  2. LS New, S Saha, MMK Ong, UA Boelsterli and ECY Chan*. Pharmacokinetic Study of Intraperitoneal Administered Troglitazone in Mice Using UPLC/MS/MS. Rapid Communications in Mass Spectrometry 21 (2007) 982-988.
  3. ECY Chan*, SL Yap, AJ Lau, PC Leow, DF Toh and HL Koh. UPLC/TOFMS Based Metabolomics of Raw and Steamed Panax notoginseng. Rapid Communications in Mass Spectrometry 21 (2007) 519-528. 

 

2000-2005

  1. HL Koh*, AJ Lau and ECY Chan. Hydrophilic interaction liquid chromatography with tandem mass spectrometry for the determination of underivatized dencichine (b-N-oxalyl-L-a,b-diaminopropionic acid) in Panax medicinal plant species. Rapid Communications in Mass Spectrometry 19 (2005) 1237-1244.
  2. ECY Chan*, TW Lee, PC Ho and LJ Fang. Modeling passive intestinal absorption of drugs using immobilized artificial membrane (IAM) chromatography and physicochemical descriptors. Journal of Chromatography A 1072 (2005) 159-168.
  3. L Bo and ECY Chan*. Application of visual basic in high-throughput mass spectrometry-directed purification of combinatorial libraries. Journal of Combinatorial Chemistry 5 (2003) 834-841.
  4. ECY Chan and PC Ho*. Preparation and characterization of immunogens for antibody production against metanephrine and normetanephrine. Journal of Immunological Methods 266 (2002) 143-154.
  5. ECY Chan*, AW Wang, WP Jia and GD Dollinger. An automated LC method for the small-scale purification of organic molecules derived from combinatorial libraries. Journal of Pharmaceutical and Biomedical Analysis 29 (2002) 139-146.

 

1998-2000

  1. ECY Chan and PC Ho*. High-performance liquid chromatography/atmospheric pressure chemical ionization mass spectrometric method for the analysis of catecholamines and metanephrines in human urine. Rapid Communications in Mass Spectrometry 14 (2000) 1959-1964.
  2. ECY Chan, PY Wee, PY Ho and PC Ho*. High-performance liquid chromatographic assay for catecholamines and metanephrines using fluorimetric detection with pre-column 9-fluorenylmethyloxycarbonyl chloride derivatization. Journal of Chromatography B 749 (2000) 179-189.
  3. ECY Chan, PY Wee and PC Ho*. Evaluation of degradation of urinary catecholamines and metanephrines and deconjugation of their sulfoconjugates using stability-indicating reversed-phase ion-pair HPLC with electrochemical detection. Journal of Pharmaceutical and Biomedical Analysis 22 (2000) 515-526.
  4. ECY Chan, PY Wee and PC Ho*. The value of analytical assays that are stability-indicating. Clinica Chimica Acta 288 (1999) 47-53.
  5. ECY Chan and PC Ho*. Enatiomeric separation of tramadol hydrochloride and its metabolites by cyclodextrin-mediated capillary zone electrophoresis. Journal of Chromatography B 707 (1998) 287-294.

     

 * corresponding author

 

media coverage

  1. Painless, cheaper way to diagnose bladder cancer. Judith Tan. The Straits Time, 22 May 2010, Sicence, pD10. 

 

book chapter

  1. PC Ho and ECY Chan. Chromatographic Measurement of Catecholamines and Metanephrines. In: Chromatographic Methods in Clinical Chemistry and Toxicology. Ed. RL Berholf and RE Winecker. John Wiley & Sons, Ltd. (March 2007) 101-119.
  2. ECY Chan, M Mal and KK Pasikanti. Metabonomics. In: Gas Chromatography. Ed. CF Poole. Elsevier (June 2012) 545-562.
  3. LY Yip and ECY Chan. Gas Chromatography/Mass spectromerty-Based Metabonomics. In: Proteomic and Metabolomic Approaches to Biomarker Discovery. Ed. TD Veenstra and HJ Issaq. Elsevier (June 2013) New!

 

international conference presentation

  1. LC Phua, CH Wilder-Smith, YM Tan, T Gopalakrishnan, RK Wong, X Li, ME Kan, J Lu, A Keshavarzian, ECY Chan. Combat-training stress mediates metabotypic changes associated with gastrointestinal symptoms and altered intestinal permeability. Digestive Diseases Week 2014, June 3-6, Chicago, IL, USA. Gastroenterology 2014, 146 (5), Suppl 1, S-533–S-534.
  2. LC Phua, YM Tan, RK Wong, X Li, CH Wilder-Smith, ECY Chan. Noninvasive urinary metabonomic diagnosis of inflammatory bowel disease using gas chromatography/mass spectrometry. Digestive Diseases Week 2014, June 3-6, Chicago, IL, USA. Gastroenterology 2014, 146 (5), Suppl 1, S-429
  3. LY Yip, HC Ku, CC Aw, WS Chen, ER Browne, R Mahendran, YK Lee, ECY Chan. Investigation of host-gut microbiome interaction in tacrine-dosed Lister-hooded rats through fecal metabolic profiling. Annual Pharmacy Research Symposium 2014, April 9, Singapore. First Prize for Postgraduate Abstract Presentation Contest (Pharmacokinetics/Toxicokinetics Category) New!
  4. LY Yip, JMX Chan, A Sampathkumar, R Mahendran, YK Lee, CC Aw, WS Chen, ER Browne, ECY Chan. Fecal microbiome profiling reveals association of β-glucuronidase producing bacteria with susceptibility to tacrine-induced hepatotoxicity. Yong Loo Lin School of Medicine 4th Annual Graduate Scientific Congress (AGSC) 2014, March 11, Singapore. Best Poster Presentation Award New!
  5. LY Yip, HC Ku, CC Aw, WS Chen, ER Browne, R Mahendran, YK Lee, ECY Chan. Investigation of host-gut microbiome interaction in tacrine-dosed Lister-hooded rats through fecal metabolic profiling. 10th International ISSX Meeting 2013, September 29-October 3, Toronto, Canada.
  6. LY Yip, JMX Chan, A Sampathkumar, R Mahendran, YK Lee, CC Aw, WS Chen, ER Browne, ECY Chan. Fecal microbiome profiling reveals association of β-glucuronidase producing bacteria with susceptibility to tacrine-induced hepatotoxicity. 10th International ISSX Meeting 2013, September 29-October 3, Toronto, Canada
  7. CY Chan, BL Nunn, DR Goodlett, SK Koh, L Zhou, ECY Chan. GluICAT: A novel liquid chromatography-mass spectrometry-based method for profiling protein glutathionylation. 10th International ISSX Meeting 2013, September 29-October 3, Toronto, Canada. Predoctoral Poster Award Finalist
  8. HT Chng, YY Dan, SJ Lin, S Aparna, HK Ho, ECY Chan. Characterization of the drug disposition transcript profile of hepatocyte-like cells derived from human fetal liver multipotent progenitor cells and human amniotic epithelial cells. ADME & Predictive Toxicology 2013, 11-12 April, Barcelona, Spain. Poster Award
  9. YJ Hong, YMF Chia, ECY Chan. Interaction of Dronedarone with Human CYP450 Enzymes: Metabolism and Inhibition. ADME & Predictive Toxicology 2013, April 11-12, Barcelona, Spain.
  10. YM Tan, HT Chng, P Chuah, SH Lam, ECY Chan. Zebrafish as an in vivo High-throughput Screening Model for CYP3A4 Induction. ADME & Predictive Toxicology 2013, April 11-12, Barcelona, Spain.
  11. LY Yip, CC Aw, WS Chen, LS New, YM Tan, ER Browne, R Mahendran, YK Lee, ECY Chan. Exploring the Interaction of Host and Gut Microbiome in the Toxicokinetics of Tacrine. Yong Loo Lin School of Medicine 3rd Annual Graduate Scientific Congress (AGSC) 2013, January 30, Singapore. Best Poster Presentation Award
  12. P Bahety, YM Tan, Y Hong, ECY Chan and PLR Ee. Gas Chromatography/Time-Of-Flight Mass Spectrometry Metabotyping of Docosahexaenoic Acid-Treated Alzheimer’s Disease Cell Model. Globalization of Pharmaceutics Education Network Meeting (GPEN) 2012, November 28 – December 1, Melbourne, Australia - Biota and Teikoku Seiyaku Co. Ltd Housing Grant and Travel Grant Award
  13. HT Chng, RFS Lee, SH Lam, Z Gong, HK Ho and ECY Chan. Zebrafish: an in vivo high-throughput screening model for CYP3A4 induction and inhibition. 19th MDO Meeting and 12th European ISSX Meeting 2012, June 17-21, the Netherlands. Predoctoral Poster Award Finalist
  14. LC Phua, PK Koh, PY Cheah, LY Yip, A Sampathkumar, YM Tan, HK Ho and ECY Chan. Global gas chromatography/time-of-flight mass spectrometry (GC/TOFMS)-based metabotyping of lyophilized human feces. 19th MDO Meeting and 12th European ISSX Meeting 2012, June 17-21, the Netherlands.
  15. LY Yip,CC Aw, WS Chen, LS New, YM Tan, ER Browne, R Mahendran, YK Lee, ECY Chan. Exploring the Interaction of Host and Gut Microbiome in the Toxicokinetics of Tacrine. 19th MDO Meeting and 12th European ISSX Meeting 2012, June 17-21, the Netherlands.
  16. HT Chng, YY Dan, SJ Lin, HK Ho and ECY Chan. Basal gene expression of drug metabolizing enzymes, transporters and nuclear receptors in hepatocyte-like cells derived from human fetal liver multipotent progenitor cells. 19th MDO Meeting and 12th European ISSX Meeting 2012, June 17-21, the Netherlands.
  17. ECY Chan, LS New, KK Pasikanti, PW Goh, LY Yip, CW Goh, CC Aw and ER Browne. Toxicometabonomics phenotyping of tacrine-induced liver transaminitis. Singapore Society for Mass Spectrometry Conference 2011, September 22-23, Singapore. First Prize SSMS-Agilent 2011 Poster Award
  18. HT Chng, HK Ho, SH Lam and ECY Chan. Isolation of zebrafish (Danio rerio) liver microsomes: protocol and considerations. 9th International ISSX Meeting 2010, September 4-8, Istanbul. Drug Metabolism Reviews 42-S1 (2010) 190–191.
  19. JW Oh, LS New, HK Ho and ECY Chan. Investigating the molecular mechanism of lapatinib-induced liver toxicity. Singapore Pharmacy Congress 2009, July 25-26, Singapore. First Prize Poster Category
  20. ECY Chan, JW Oh, LS New and HK Ho. Investigating the molecular mechanism of lapatinib-induced liver toxicity". ISSX 3rd Regional Asia Pacific Meeting 2009, May 09-12, Bangkok. Drug Metabolism Reviews 41-S2 (2009) 89.
  21. LS New, CW Yap, LT Goh and ECY Chan. Pharmaceutical metabolite profiling using quadrupole/ion mobility spectrometry/time-of-flight mass spectrometry. ISSX 3rd Regional Asia Pacific Meeting 2009, May 09-12, Bangkok. Drug Metabolism Reviews 41-s2 (2009) 53.
  22. X Ma and ECY Chan. Fluorescence-based screening of pharmaceutical reactive metabolites using glutathione immobilized 96-well microsomal assay. ISSX 3rd Regional Asia Pacific Meeting 2009, May 09-12, Bangkok. Drug Metabolism Reviews 41-s2 (2009) 26-27. First Prize Postdoctoral Fellow Category
  23. S Saha, LS New, HK Ho, WK Chui and ECY Chan. Investigation of the role of thiazolidinedione of troglitazone in inducing hepatotoxicity in humans. ISSX 3rd Regional Asia Pacific Meeting 2009, May 09-12, Bangkok. Drug Metabolism Reviews 41-s2 (2009) 26.
  24. KK Pasikanti, J Norasmara, R Mahendran, K Esuvaranathan, PC Ho and ECY Chan. Extracellular metabonomics of human non-tumorigenic and tumorigenic uroepithelial cells. Metabolomics 2008, September 2-6, Boston.

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