Faculty of Science

Department of Pharmacy

 
   

 

scientific publication

 

international peer reviewed article

2015

  1. HK Ho, CY Chan, KD Hardy and ECY Chan. Mechanism-based inactivation of CYP450 enzymes: a case study of lapatinib. Drug Metabolism Review In Press. New!
  2. TP Lim, YY Cai, YJ Hong, ECY Chan, S Suranthran, J Teo, W Lee, TY Tan, LY Hsu, TH Koh, TT Tan and AL Kwa*. In-vitro Pharmacodynamics of Various Antibiotics in Combination against Extensively Drug-Resistant Klebsiella pneumoniae. Antimicrobial Agents and Chemotherapy In Press. New! 
  3. ECY Chan*, KK Pasikanti, YJ Hong, PC Ho, R Mahendran, LRN Mani, E Chiong and K Esuvaranathan*. Metabonomic profiling of bladder cancer.Journal of Proteome Research 14(2) (February 2015) 587-642.
  4. KL Chang, HN Pee, WP Tan, GS Dawe, E Holmes, JK Nicholson, ECY Chan and PC Ho*. Metabolic profiling of CHO-AßPP695 cells revealed mitochondrial dynsfunction prior to Aß pathology and potential therapeutic effects of both PPARγ and PPARα agonisms for Alzheimer’s disease. Journal of Alzheimer's Disease 44 (2015) 215-231 
2014
  1. LC Phua, HW Ng, AHL Yeo, E Chen, MSM Lo, PY Cheah, ECY Chan, PK Koh* and HK Ho*. Prevalence of KRAS, BRAF, PI3K and EGFR mutations among Asian metastatic colorectal cancer patients. Oncology Letters (2014) in press 
  2. LC Phua, XP Chue, PK Koh, PY Cheah, ECY Chan* and HK Ho*. Global fecal microRNA profiling in the identification of biomarkers for colorectal cancer screening among Asians. Oncology Reports 32 (May 2014) 97-104.
  3. EA Bard-Chapeau, A Nguyen, AG Rust, A Sayadi, P Lee, BQ Chua, LS New, J de Jong, JM Ward, CKY Chin, V Chew, HC Toh, J Abastado, T Benoukraf , R Soong, FA Bard, AJ Dupuy, RL Johnson, GK Radda, ECY Chan, LFA Wessels, DJ Adams, NA Jenkins and NG Copeland*. Transposon mutagenesis identifies genes driving hepatocellular carcinoma in a chronic hepatitis B mouse model. Nature Genetics 46 (January 2014) 24-32.
  4. MD Damavandi, ECY Chan, JP Kraus, PC Ho and TS Kang*. Development of an UPLC-MS/MS method for assaying the enzymatic activity of propionyl coenzyme-A carboxylase. Bioanalysis 6 (February 2014) 335-348.
  5. LC Phua, XP Chue, PK Koh, PY Cheah, HK Ho* and ECY Chan*. Non-invasive fecal metabonomic detection of colorectal cancer. Cancer Biology & Therapy 15 (April 2014) 389-397. 
  6. P Bahety, YM Tan, Y Hong, L Zhang, ECY Chan* and PL Ee*. Metabotyping of docosahexaenoic acid - treated Alzheimer’s disease cell model. PLOS ONE (February 2014) DOI: 10.1371/journal.pone.0090123.

2013

  1. LC Phua, PK Koh, PY Cheah, HK Ho* and ECY Chan*. Global gas chromatography/time-of-flight mass spectrometry (GC/TOFMS)-based metabonomic profiling of lyophilized human feces. Journal of Chromatography B 937 (October 2013) 103-113.
  2. KK Pasikanti, K Esuvaranathan,YJ Hong, PC Ho, R Mahendran, LRN Mani, E Chiong and ECY Chan*. Urinary metabotyping of bladder cancer using two-dimensional gas chromatography time-of-flight mass spectrometry. Journal of Proteome Research 12 (September 2013) 3865-3873.
  3. BD Prakash, K Esuvaranathan,PC Ho, KK Pasikanti, ECY Chan and CW Yap*. An automated Pearson's correlation change classification (APC3) approach for GC/MS metabonomic data using total ion chromatogram (TIC). Analyst 138 (May 2013) 2883-2889. 
  4. HH Cheong, J Masilamani, ECY Chan, SY Chan* and TT Phan*. Metabolically functional hepatocyte-like cells from human umbilical cord lining epithelial cells. Assay and Drug Development Technologies 11 (March 2013) 130-138.
  5. LC Phua, M Mal, PK Koh, PY Cheah, ECY Chan* and HK Ho*. Investigating the roles of nucleoside transporters in the resistance of colorectal cancer to 5-fluorouracil therapy. Cancer Chemotherapy and Pharmacology 71 (March 2013) 817-823.
  6. LS New, TP Lim, JW Oh, GJS Cheah, AL Kwa and ECY Chan*. Optimizing hollow-fiber-based pharmacokinetic assay via chemical stability study to account for inaccurate simulated clearance of rifampicin. Analytical and Bioanalytical Chemistry 405 (4) (January 2013) 1407-1415.

2012

  1. ZP Hu, ER Browne, T Liu, TE Angel, PC Ho and ECY Chan*. Metabonomic profiling of TASTPM transgenic Alzheimer's disease mouse model. Journal of Proteome Research 11 (December 2012) 5903-5913.
  2. S Saha, DSZ Chan, CY Lee, W Wong, LS New, WK Chui, ECY Chan* and HK Ho*. Pyrrolidinediones reduce the toxicity of thiazolidinediones and modify their anti-diabetic and anti-cancer properties. European Journal of Pharmacology 697 (December 2012) 13-23.
  3. YL Teo, M Saetaew, S Chanthawong, YS Yap, ECY Chan, HK Ho and A Chan*. Effect of CYP3A4 inducer dexamethasone on hepatotoxicity of lapatinib: clinical and in vitro evidence. Breast Cancer Research and Treatment 133 (June 2012) 703-711.
  4. WPK Ching, SH Thng, AP Hui, DY Lee, ECY Chan* and YS Ho*. LC-MS-based metabolic characterization of high monoclonal antibody-producing chinese hamster ovary cells. Biotechnology and Bioengineering 109 (December 2012) 3103-3111.
  5. ECY Chan*, LS New, TB Chua, CW Yap, HK Ho and SD Nelson. Interaction of lapatinib with cytochrome P450 3A5. Drug Metabolism & Disposition 40 (July 2012) 1414-1422.
  6. HT Chng, HK Ho, CW Yap, SH Lam and ECY Chan*. An investigation of the bioactivation potential and metabolism profile of zebrafish versus human. Journal of Biomolecular Screening 17 (August 2012) 974-986.
  7. ECY Chan*. Thomas O. Metz (Ed.): Metabolic profiling. Methods and protocols. Analytical Bioanalytical Chemistry 403 (July 2012) 2465-2466.
  8. M Mal, PK Koh, PY Cheah and ECY Chan*. Metabotyping of human colorectal cancer using two-dimensional gas chromatography mass spectrometry. Analytical Bioanalytical Chemistry 403 (April 2012) 483-493.

2011

  1. T Nema, ECY Chan and PC Ho*. Efficiency of a miniaturized silica monolithic cartridge in reducing matrix ions as demonstrated in the simultaneous extraction of morphine and codeine from urine samples for quantification with liquid chromatography-tandem mass spectrometry (LC-MS/MS). Journal of Mass Spectrometry 46 (September 2011) 891-900.
  2. LY Chen, L Zhou*, ECY Chan*, J Neo and R Beuerman. Characterization of the human tear metabolome by LC-MS/MS. Journal of Proteome Research 10 (October 2011) 4876-4882.
  3. CY Chan, LS New, HK Ho and ECY Chan*. Reversible time-dependent inhibition of cytochrome P450 enzymes by duloxetine and inertness of its thiophene ring towards bioactivation. Toxicology Letters 206 (October 2011) 314-324.
  4. KM Banday, KK Pasikanti, ECY Chan, R Singla, KVS Rao, VA Chauhan* and RK Nanda*. Urine volatile organic compounds could discriminate tuberculosis patients from healthy subjects. Analytical Chemistry 83 (2011) 5526-5534.
  5. ECY Chan*, KK Pasikanti and JK Nicholson. Global urinary metabolic profiling procedures using gas chromatography mass spectrometry. Nature Protocols 6 (October 2011) 1483-1499.
  6. T Nema, ECY Chan and PC Ho*. Extraction of ketamine from urine using a miniature silica monolithic cartridge followed by quantification with liquid chromatography tandem mass spectrometry (LC-MS/MS). Journal of Separation Science 10 (2011) 2079-2087.
  7. KL Chang, LS New, M Mal, CW Goh, CC AW, ER Browne and ECY Chan*. Metabolic profiling of 3-nitroproprionic acid early-stage Huntington's disease rat model using gas chromatography time-of-flight mass spectrometry. Journal of Proteome Research 10 (2011) 2079-2087.
  8. H Takakusa, MD Wahlin, C Zhao, KL Hanson, LS New, ECY Chan and SD Nelson*. Metabolite-intermediate complex formation of human cytochrome P450 3A4 by lapatinib. Drug Metabolism & Disposition 39 (2011) 1022-1030.
  9. H Sukardi, HT Chng, ECY Chan, Z Gong and SH Lam*. Zebrafish for drug toxicity screening: bridging the in vitro cell-based models and in vivo mammalian models. Expert Opinion on Drug Metabolism and Toxicology 7 (2011) 579-589.
  10. DF Toh, DN Patel, ECY Chan, A Yeo, SY Neo and HL Koh*. Anti-proliferative effects of raw and steamed extracts of Panax notoginseng and its ginsenoside constituents on human liver cancer cells. Chinese Medicine 6 (2011) 1-9.
  11. M Mal, PK Koh, PY Cheah and ECY Chan*. UPLC/MS/MS targeted profiling of arachidonic acid and eicosanoids in human colorectal cancer. Rapid Communications in Mass Spectrometry 25 (2011) 755-764.
  12. DJY Ng, KK Pasikanti and ECY Chan*. Trend analysis of metabonomics and systemic review of metabonomics-derived cancer marker metabolites. Metabolomics 7 (2011) 155-178.

2010

  1. YT Koh, KK Pasikanti, CW Yap* and ECY Chan*. Comparative evaluation of software for retention time alignment of gas chromatography/time-of-flight mass spectrometry-based metabonomic data. Journal of Chromatography A 1217 (2010) 8308-8316.
  2. KK Pasikanti, J Norasmara, S Cai, R Mahendran, K Esuvaranathan, PC Ho and ECY Chan*. Metabolic footprinting of tumorigenic and non-tumorigenic uroepithelial cells using two-dimensional gas chromatography time-of-flight mass spectrometry. Analytical and Bioanalytical Chemistry 398 (2010) 1285-1293.
  3. WC Teng, JW Oh, LS New, MD Wahlin, SD Nelson, HK Ho and ECY Chan*. Mechanism-based inactivation of cytochrome P450 3A4 by lapatinib. Molecular Pharmacology 78 (2010) 693-703.
  4. T Nema, ECY Chan and PC Ho*. Application of silica based monolith as solid phase extraction cartridge for extracting polar compounds from urine. Talanta 82 (2010) 488-494.
  5. X Ma and ECY Chan*. On-line chromatographic screening of matrix metalloproteinase inhibitors using immobilized MMP-9 enzyme reactor. Journal of Chromatography B 878 (2010) 1777-1783.
  6. KK Pasikanti, K Esuvaranathan, PC Ho, R Mahendran, R Kamaraj, QH Wu, E Chiong and ECY Chan*. Noninvasive urinary metabonomic diagnosis of human bladder cancer. Journal of Proteome Research 9 (2010) 2988-2995.   
  7. S Saha, LS New, HK Ho, WK Chui, ECY Chan*. Direct toxicity effects of sulfo-conjugated troglitazone on human hepatocytes. Toxicology Letters 195 (2010) 135-141.  
  8. DF Toh, LS New, HL Koh* and ECY Chan*. Ultra-high performance liquid chromatography / time-of-flight mass spectrometry (UHPLC/TOFMS) for time-dependent profiling of raw and steamed Panax notoginsengJournal of Pharmaceutical and Biomedical Analysis 52 (2010) 43-50.
  9. S Saha, LS New, HK Ho, WK Chui and ECY Chan*. Investigation of the role of the thiazolidinedione ring of troglitazone in inducing hepatotoxicity. Toxicology Letters 192 (2010) 141-149.
  10. X Ma and ECY Chan*. Fluorescence-based liver microsomal assay for screening of pharmaceutical reactive metabolites using glutathione conjugated 96-well plates. Bioconjugate Chemistry 21 (2010) 46-55.
  11. HT Chng, LS New, AH Neo, CW Goh, ER Browne and ECY Chan*. A sensitive LC/MS/MS bioanalysis assay of orally-administered lipoic acid in rat blood and brain tissue. Journal of Pharmaceutical and Biomedical Analysis 51 (2010) 754-757.

2009

  1. DPQ Goh, AH Neo, CW Goh, CC Aw, LS New, WS Chen, Z Atcha, ER Browne and ECY Chan*. Metabolic Profiling of Rat Brain and Cognitive Behavioral Tasks: Potential Complementary Strategies in Preclinical Cognition Enhancement Research. Journal of Proteome Research 8 (2009) 5679-5690.
  2. R  Kashimshetty, VG Desai, VM Kale, T Lee, CL Moland, WS Branham, LS New, ECY Chan, H Younis and UA Boelsterli*. Underlying mitochondrial dysfunction triggers flutamide-induced oxidative liver injury in a mouse model of idiosyncratic drug toxicity. Toxicology and Applied Pharmacology 238 (2009) 150-159.
  3. M Mal, PK Koh, PY Cheah and ECY Chan*. Development and validation of a gas chromatography mass spectrometry (GC/MS) method for the metabolic profiling of human colon tissue. Rapid Communications in Mass Spectrometry 23 (2009) 487-494.
  4. ECY Chan*, LS New, CW Yap and LT Goh. Pharmaceutical metabolite profiling using quadrupole/ ion mobility spectrometry/ time-of-flight mass spectrometry. Rapid Communications in Mass Spectrometry 23 (2009) 384-394.
  5. ECY Chan*, PK Koh, M Mal, PY Cheah, KW Eu, A Backshall, R Cavill, JK Nicholson and H Keun. Metabolic profiling of human colorectal cancer using high-resolution magic angle spinning nuclear magnetic resonance (HR-MAS NMR) spectroscopy and gas chromatography mass spectrometry (GC/MS). Journal of Proteome Research 8 (2009) 351-361.
  6. HT Chng, LS New, AH Neo, CW Goh, ER Browne and ECY Chan*. Distribution study of orally administered lipoic acid in rat brain tissues. Brain Research 1251 (2009) 80-86.

 2008

  1. KK Pasikanti, PC Ho and ECY Chan*. Development and validation of a GC/MS metabonomic platform for the global profiling of urinary metabolites. Rapid Communications in Mass Spectrometry 22 (2008) 2984-2992.
  2. LC Phua, LS New, CW Goh, AH Neo, ER Browne and ECY Chan*. Investigation of the drug-drug Interaction between α-lipoic Acid and valproate via mitochondrial β-oxidation. Pharmaceutical Research 25 (2008) 2639-2649.
  3. WS Law, PY Huang, ES Ong*, CN Ong, SFY Li, KK Pasikanti, ECY Chan. Metabonomics investigation of human urine after ingestion of green tea with gas chromatography/mass spectrometry, liquid chromatography/mass spectrometry and 1H NMR spectroscopy. Rapid Communications in Mass Spectrometry 22 (2008) 2436-2446.
  4. SC Tan, LS New and ECY Chan*. Prevention of acetaminophen (APAP) induced hepatotoxicity by leflunomide via inhibition of APAP biotransformation to N-acetyl-p-benzoquinone imine. Toxicology Letters 180 (2008) 174-181.
  5. QM Seah, LS New, ECY Chan, UA Boelsterli*. Oxidative bioactivation and toxicity of leflunomide in immortalized human hepatocytes and kinetics of the non-enzymatic conversion to its major metabolite, A77-1726. Drug Metabolism Letters 2 (2008) 153-157.
  6. KK Pasikanti, PC Ho and ECY Chan*. Gas Chromatography/Mass Spectrometry in Metabolic Profiling of Biological Fluids. Journal of Chromatography B 871 (2008) 202-211. Top 25 Most Cited Review Article (2008-2009)  
  7. LS New and ECY Chan*.Evaluation of BEH C18, BEH HILIC and HSS T3 (C18) Column Chemistries for the UPLC/MS/MS Analysis of Glutathione, Glutathione Disulfide and Ophthalmic Acid in Mouse Liver and Human Plasma.  Journal of Chromatographic Science 48 (2008) 209-214 (Special UPLC Issue).

2007

  1. ECY Chan* and LS New. In Vitro Metabolism of Leflunomide by Mouse and Human Liver Microsomes. Drug Metabolism Letters 1 (2007) 299-305. 
  2. LS New, S Saha, MMK Ong, UA Boelsterli and ECY Chan*. Pharmacokinetic Study of Intraperitoneal Administered Troglitazone in Mice Using UPLC/MS/MS. Rapid Communications in Mass Spectrometry 21 (2007) 982-988.
  3. ECY Chan*, SL Yap, AJ Lau, PC Leow, DF Toh and HL Koh. UPLC/TOFMS Based Metabolomics of Raw and Steamed Panax notoginseng. Rapid Communications in Mass Spectrometry 21 (2007) 519-528. 

2000-2005

  1. HL Koh*, AJ Lau and ECY Chan. Hydrophilic interaction liquid chromatography with tandem mass spectrometry for the determination of underivatized dencichine (b-N-oxalyl-L-a,b-diaminopropionic acid) in Panax medicinal plant species. Rapid Communications in Mass Spectrometry 19 (2005) 1237-1244.
  2. ECY Chan*, TW Lee, PC Ho and LJ Fang. Modeling passive intestinal absorption of drugs using immobilized artificial membrane (IAM) chromatography and physicochemical descriptors. Journal of Chromatography A 1072 (2005) 159-168.
  3. L Bo and ECY Chan*. Application of visual basic in high-throughput mass spectrometry-directed purification of combinatorial libraries. Journal of Combinatorial Chemistry 5 (2003) 834-841.
  4. ECY Chan and PC Ho*. Preparation and characterization of immunogens for antibody production against metanephrine and normetanephrine. Journal of Immunological Methods 266 (2002) 143-154.
  5. ECY Chan*, AW Wang, WP Jia and GD Dollinger. An automated LC method for the small-scale purification of organic molecules derived from combinatorial libraries. Journal of Pharmaceutical and Biomedical Analysis 29 (2002) 139-146.

1998-2000

  1. ECY Chan and PC Ho*. High-performance liquid chromatography/atmospheric pressure chemical ionization mass spectrometric method for the analysis of catecholamines and metanephrines in human urine. Rapid Communications in Mass Spectrometry 14 (2000) 1959-1964.
  2. ECY Chan, PY Wee, PY Ho and PC Ho*. High-performance liquid chromatographic assay for catecholamines and metanephrines using fluorimetric detection with pre-column 9-fluorenylmethyloxycarbonyl chloride derivatization. Journal of Chromatography B 749 (2000) 179-189.
  3. ECY Chan, PY Wee and PC Ho*. Evaluation of degradation of urinary catecholamines and metanephrines and deconjugation of their sulfoconjugates using stability-indicating reversed-phase ion-pair HPLC with electrochemical detection. Journal of Pharmaceutical and Biomedical Analysis 22 (2000) 515-526.
  4. ECY Chan, PY Wee and PC Ho*. The value of analytical assays that are stability-indicating. Clinica Chimica Acta 288 (1999) 47-53.
  5. ECY Chan and PC Ho*. Enantiomeric separation of tramadol hydrochloride and its metabolites by cyclodextrin-mediated capillary zone electrophoresis. Journal of Chromatography B 707 (1998) 287-294.

 

book chapter

  1. LY Yip and ECY Chan. Gas Chromatography/Mass spectromerty-Based Metabonomics. In: Proteomic and Metabolomic Approaches to Biomarker Discovery. Ed. TD Veenstra and HJ Issaq. Elsevier (June 2013) New!
  2. ECY Chan, M Mal and KK Pasikanti. Metabonomics. In: Gas Chromatography. Ed. CF Poole. Elsevier (June 2012) 545-562.
  3. PC Ho and ECY Chan. Chromatographic Measurement of Catecholamines and Metanephrines. In: Chromatographic Methods in Clinical Chemistry and Toxicology. Ed. RL Berholf and RE Winecker. John Wiley & Sons, Ltd. (March 2007) 101-119.

 * corresponding author

 

media coverage

  1. Painless, cheaper way to diagnose bladder cancer. Judith Tan. The Straits Time, 22 May 2010, Sicence, pD10.