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SEMINAR ANNOUNCEMENT


In-vitro Investigation of Phytochemicals for Wound Healing

by

Mr. Phan Toan Thang
Department of Pharmacy
National University of Singapore

on

Date: Friday, 27th December 2002
Time: 1400 - 1500 hrs
Venue: S4-05-10


Synopsis:

Using in-vitro wound healing models to investigate the extract for wound healing from plant named Chromoleana odorata, it was found that this plant extract has effects that enhance wound healing; stimulate cell proliferation, migration and deposition of essential molecules and act as an antioxidant. A mixture of phenolic compounds was identified in the extract and these proved to have antioxidant effects.
Among the dietary substances screened, Quercetin was also shown to be most effective on in vitro skin cell cutures for the treatment of keloids and hypertrophic scars by blocking two major pro-fibrotic systems, inhibition of keloid fibroblast proliferation and production of collagen and matrix, inhibition of wound contraction.



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