SEMINAR ANNOUNCEMENT

PhD Thesis Defence Seminar

Clinical Pharmacokinetics of Tacrolimus in Asian Liver Transplant Patients

by

Mr. SAM Wai Johnn
Department of Pharmacy
National University of Singapore

on

Date: Friday, 19th March 2004
Time: 1000 - 1100 hrs
Venue: SR2 (S2-04-11) DBS

Synopsis:

The general aim of the thesis is to investigate the population pharmacokinetics (PK) of tacrolimus (Tac) (FK506) in the local Asian liver transplant recipients so as to identify possible relationships between clinical covariates and population parameter estimates. This can be achieved by (A) determining the population PK of Tac in the local Asian paediatric liver transplant recipients, which represents a special subpopulation with special PK characteristics, and (B) determining the population PK of Tac in the local Asian adult and paediatric liver transplant recipients. Population modeling using the nonlinear mixed effects model (NONMEM) program was performed on the population data set in the 2 studies to derive population models.

The population models have identified significant relationships in Asian liver transplant patients between the PK of Tac and arthropometric characteristics of the patients, as well as the clinical conditions of the patients. Using these models, in conjunction with Bayesian forecasting, a truly individualized immunosuppressive therapy of Tac can be developed and applied.

ALL ARE WELCOME