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SEMINAR ANNOUNCEMENT
PhD Thesis Defence Seminar
Particle Development for Drug Delivery
by
Mr. LEE Chin Chiat
Department of Pharmacy
National University of Singapore
on
Date: Saturday, 17th April 2004
Time: 1000 - 1100 hrs
Venue: S4 Level 5 Tutorial Room
Synopsis:
Particle development is an important first-stage
process in the development of a drug delivery system. Common industrial
processes are known to affect the morphological characteristics
of particles produced. This project was directed to the study of
the effects of starting materials and process variables of milling
and particle classification, on the morphological characteristics
of particles produced. The fluidised bed hammer mill (50 ZPS, Hosokawa
Micron Corporation) and fluidised bed opposed jet mill (100 AFG,
Hosokawa Micron Corporation) were employed for milling, whereas
an air classifying system (50 ATP, Hosokawa Alpine AG) was investigated
for particle classification. Correlations between the characteristics
of starting materials and process variables to the size and shape
of the particles produced were found. The two milling processes
were subsequently used to produce drug of varying sizes for the
formulation of interactive mixtures and solid dispersions, with
a soluble carrier, for dissolution enhancement of a practically
insoluble drug. Particle development facilitated the understanding
of the dissolution mechanisms of interactive mixtures and solid
dispersions.
Keywords: Fluidised bed hammer mill; Fluidised bed opposed jet mill;
Air classifying system; Practically insoluble drug; Interactive
mixtures; Solid dispersions
ALL ARE WELCOME
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