SEMINAR ANNOUNCEMENT

PhD Thesis Defence Seminar

Retinoids: Formulation development and efficacy evaluation in Melanoma Cells

by

Ms. LIU Xin
Department of Pharmacy
National University of Singapore

on

Date: Tuesday, 11th October 2005
Time: 0830 - 0930hrs
Venue: S4 Level 5 Room 16, Tutorial Room

Abstract:

Cyclodextrin-based formulations of retinoids were developed to improve their solubility, photostability and bioavailability, and the effects of retinoids on murine melanoma cells were investigated. Molecular modeling was carried out to verify the experimental results. Pharmacokinetic properties of newly developed cyclodextrin-based formulations were studied on Sprague-Dawley rats. The anti-proliferation and anti-metastasis effects of retinoids were tested in cell culture model and tumor model of melanoma. The results showed that aqueous solubility and photostability of acitretin and 13-cis-RA were dramatically improved by inclusion into cyclodextrins. Molecular modeling studies were consistent with phase solubility studies. Cyclodextrin-based formulation of acitretin could improve its oral bioavailability and decrease the variation of its oral pharmacokinetics. The anti-proliferation and anti-metastasis effects of retinoids were confirmed in B16-F10 cells and experimental lung metastasis model.

Keywords: retinoid; cyclodextrin; formulation; pharmacokinetics; melanoma; metastasis.

ALL ARE WELCOME