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SEMINAR ANNOUNCEMENT
Transcriptional and post-transcriptional regulation
of ATP-binding cassette (ABC) transporters
by
Dr Rachel Ee Pui Lai
Postdoctoral Fellow
ProStrakan Pharmaceuticals
Paris, France
on
| Date: |
Thursday, 1st Dec 2005 |
| Time: |
10.00am |
| Venue: |
Seminar Room (S4-05-16)
Department of Pharmacy |
Synopsis:
The study of expression and function of ABC transporters
in cancer is important for two reasons: (i) ABC transporters are
often expressed in tumors and other malignancies treated with anticancer
drugs and easily render these tumor cells resistant to treatment
within a short period of time; and (ii) the pharmacokinetics of
anticancer drugs are often affected by the presence of ABC transporters
in the liver and intestines, resulting in reduced oral bioavailability
and increased elimination. Therefore, insights into the mechanisms
governing their expression and opportunities to modulate these mechanisms
are highly relevant. The overall objective of this work was thus
to examine aspects of the regulation of gene expression of the ABC
transporters. Given the complexity of the gene regulation processes,
this work was focused on understanding the aspect of transcriptional
and post-transcriptional regulation of two important members of
the ABC transporter superfamily, namely BCRP and MRP1. The rationale
of this work was to improve our understanding of the network of
regulatory mechanisms of ABC transporters involved in drug resistance
so that we can have an impact on cancer therapy.
ALL ARE WELCOME
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