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SEMINAR ANNOUNCEMENT
Design and evaluation of Selective adenosine
receptors antagonists and Development of FUNctionalized carbon nanotubes
as delivery systems
by
Dr Giorgia Pastorin
Institut de Biologie Moleculaire et Cellulaire
France
on
| Date: |
Wednesday, 11 Jan 2006 |
| Time: |
10.00am |
| Venue: |
Seminar Room (S4-05-16)
Department of Pharmacy |
Synopsis:
The selective modulation of Adenosine receptors represents
the basis for understanding the pathophysiological role of such
unknown receptors. In particular, it has already been reported that
some pyrazolotriazolopyrimidines resulted to be highly potent antagonists
of the human A3 subtype, whose inhibition seems to be useful in
the treatment of inflammation and regulation of cell growth. Starting
from that, we decided to synthetize new compounds that allowed us
to evaluate the effects of each substituent both from a chemical
and a sterical point of view. This study was associated to a molecular
modeling evaluation to support the results and to suggest the design
of new potent antagonists.
Recently, carbon nanotubes (CNT) have attracted the attention of
several scientists, due to their unique and intriguing structure
and properties. These nanoobjects hold a lot of promises for application
in medicinal chemistry for different reasons: inducible water solubility,
high stability of the dispersion, lack of intrinsic immunogenicity
and an efficient loading capacity. Functionalization of the surface
of CNT has allowed not only a great improvement of their solubility,
but also paved the way to new interesting applications, as suggested
by their recent use as vectors for internalization into the cell
of therapeutic molecules.
In this Communication, I will cover my main research interests.
In the first part I will talk about the design, the synthesis and
the QSAR profile of some policyclic systems as potent adenosine
antagonists. In the second part, I will describe an efficient strategy
for the funcionalization of carbon nanotubes and some examples of
their potential biological applications in the field of drug delivery,
together with a brief evaluation of the important issue concerning
their toxicity.
ALL ARE WELCOME
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