SEMINAR ANNOUNCEMENT

The use of vesicle carrier systems for dermal and transdermal delivery

by

Professor Bouwstra, J. A.
Department of Drug Delivery Technology
Leiden/Amsterdam Center for Drug Research
Leiden University
The Netherland

on

Synopsis:

The use of vesicles to enhance dermal and transdermal drug transport has gained much interest in the last decade. In the early nineties, the use of elastic vesicles was introduced. These are a novel type of liquid-state vesicles, characterized by elastic, deformable lipid membranes. The vesicle elasticity was obtained by combining stabilizing and destabilizing molecules within one lipid membrane. Two mechanisms can be proposed. Firstly, the elastic vesicles can act as penetration enhancers, whereby vesicle components enter the stratum corneum (SC) and subsequently modify the intercellular lipid lamellae (mechanism 1). Secondly, the elastic vesicles can act as drug carrier systems, whereby intact vesicles can enter the SC carrying vesicle-bound drug molecules into the skin (mechanism 2). In this lecture we will address both, the mechanism of action of elastic vesicles and the effect on drug transport across the skin. In vitro as well as in vivo studies will be described. Finally the use of elastic vesicles as tool for dermal vaccination will be addressed.

ALL ARE WELCOME